By Carolyn Stephenson, EVP, Central Strategy Lead, and Kathy Moriarty, VP, Integrated Strategy

In the complex world of rare diseases, the secret to launching successful treatments lies in deeply understanding our audience: patients, physicians, and caregivers. Each group has a distinct identity that shapes their decisions and behaviors. By tapping into these identities through Predictive Storytelling—a technique that utilizes data, human behavior, and market dynamics—we not only anticipate the future but actively shape it. This proactive strategy ensures our initiatives are as transformative as they are innovative.

Understanding How Identity Drives Intention in Healthcare
In rare disease healthcare, intention is more than just a fleeting thought—it's about the values, motivational styles, and contexts that influence perceptions and decisions. This intricate weave of factors makes each patient, physician, and caregiver uniquely complex.

  • Values: Core principles guide our actions. Physicians might be driven by Prestige, seeking peer recognition, or by Service, focusing on patient well-being. Patients may prioritize Stability, holding on to their current health status, or Innovation, driven by the curiosity to explore new treatments. Understanding these values allows us to craft messages that deeply resonate with each individual’s worldview.
  • Context: This encompasses the specific circumstances influencing our experiences. For physicians, context might be shaped by their specialty or tenure, affecting their openness to innovations. For patients, it could include the presence of a caregiver or cultural influences, which color their interactions with the healthcare system.
  • Motivational Style: This defines our driving forces. Promoters are fueled by aspirations and possibilities, viewing each new treatment as an opportunity for improvement. Conversely, Preventers are motivated by duties and risk aversion, requiring solid assurances before embracing change.

Recognizing these intention facets is crucial for communicators. It allows us to develop messages that are not just informative but deeply compelling. By aligning our communication strategies with the unique aspirations of each stakeholder, we create a more receptive environment, significantly boosting the likelihood of treatment adoption.

The Power of Predictive Storytelling
Gathering and analyzing the nuanced details of each stakeholder’s intentions—values, motivational styles, and contextual factors—might seem daunting, but Predictive Storytelling excels here. This method uses advanced analytics to simplify and streamline the interpretation of complex data sets, providing a clear vision for proactive action.

Predictive Storytelling goes beyond forecasting; it actively molds the future. By understanding and anticipating the need for varied narratives that connect to emotional desires, we tailor communications that not only reach but profoundly engage each individual. This foresight allows us to stay ahead of changes, ensuring our messages are always relevant and impactful.

Strategic Applications in Rare Disease Engagement
Conventional marketing falls short in the rare disease sector. Here are three innovative strategies to effectively leverage intention-driven marketing:

  • Hyper-Personalized Engagement Strategies: Tailor engagement strategies to address the unique desires and aspirations of each patient, using advanced analytics to predict and adapt to individual patient journeys. This involves creating communication plans that cater to the patient’s emotional and psychological needs.
  • Community and Relationship Building Initiatives: Foster long-term relationships with patient advocacy groups and specialized healthcare providers to deepen our understanding of patient and physician identities and needs. Utilize these insights to support community-driven networks and enhance trust and communication, aligning programs with the community’s values and motivations to encourage treatment adoption.
  • Adaptive Content and Message Framing: Employ Predictive Storytelling to dynamically adapt marketing content and strategies in line with evolving desires and circumstances. Develop messaging that directly addresses the emerging trends and needs of the rare disease community, ensuring relevance and resonance at every touchpoint.


Understanding and engaging with the intentions of those within the rare disease community is vital for encouraging the adoption of new treatments. Although Predictive Storytelling is a valuable tool, it's the profound engagement with diverse intentions that unlocks potential and catalyzes change. By focusing on these insights, stakeholders can devise strategies that not only resonate more deeply but also achieve higher uptake rates.




About the Author:

Syneos Health Communications is a portfolio of innovative health-first, health-only advertising, branding, creative, medical communications, market access, and public relations agencies – powered by a global network of clinical and commercial minds across Syneos Health that are engaged at every point of influence in health.